Alex Troster will be presenting the following 3-hour workshop at our conference in November.
Much research continues to be devoted to
the early diagnosis and treatment of the most common dementia, Alzheimer’s
disease. In the last two decades, however, increasing attention has been paid
to what were traditionally referred to as “subcortical dementias,” Parkinson’s
disease (PD) dementia (PDD) and the rarer dementia associated with Huntington’s
disease (HD). The first part of this workshop will deal with the rarer HD and
atypical parkinsonian syndromes such as progressive supranuclear palsy,
corticobasal degeneration, and multiple system atrophy. In the case of HD,
particular emphasis will be placed on preclinical neuropsychological
characteristics and recent questions about the implications of an
“indeterminate” number of CAG repeats. Recent AAN treatment guidelines will
also be summarized. For each atypical parkinsonian disorder recent advances in
understanding the neural substrates of the disorder (including neuroimaging
findings) and treatments are discussed. The neuropsychological differentiation
of tauopathies from alpha synucleinopathies, and atypical from typical
parkinsonian syndromes will be highlighted. Neuropsychological profiles of some
clinical cases will be discussed. The second half of the workshop deals with PD
and, consistent with recent research, emphasis is placed on mild cognitive
impairment, potential imaging and biomarkers (e.g., beta amyloid and
phosphorylated tau), and outcomes of treatments such as gene therapy and deep
brain stimulation. The neuropsychological features associated with early
dopaminergic deficits are described and differentiated from those probably
related to other neurotransmitter abnormalities. Recent diagnostic criteria for
PD MCI, and the special emphasis of neuropsychology in them, will be described.
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